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Scientific References – Digestive Enzymes

  1. Haq SK, Rasheedi R, Khan RH (2002) Characterization of a partially folded intermediate of stem bromelain at low pH. Eur J Biochem. 269: 47-52.
  2. Klein G, Kullich W (2000) Short-term treatment of painful osteoarthritis of the knee with oral enzymes. Clin Drug Invest. 19 (1): 15-23.
  3. Brakebusch M, Wintergerst U, Petropoulou T, Notheis G, Husfeld L, et al. (2001) Bromelain is an accelerator of phagocytosis, respiratory burst and killing of Candida albicans by human granulocytes and monocytes. Eur J Med Res. 6 (5): 193-200.
  4. Dresser L, Rehberger A, Kokron E, Paukovits W (1994) Proteolytic enzymes and amylase induce cytokine production in human peripheral blood mononuclear cells in vitro. Cancer Biother. 9 (3): 253-63.
  5. Kleine MW, Stauder GM, Beese EW (1995) The intestinal absorption of orally administered hydrolytic enzymes and their effects in the treatment of acute herpes zoster as compared with those of oral acyclovir therapy. Phytomedicine. 2 (1): 7-15.
  6. Taussig SJ, Szakerczes J, Batkin S ((1985) Inhibition of tumor growth in vitro by bromelain, an extract of the pineapple plant (Ananas comosus). Planta Med. 6: 538-539.
  7. Gamer, MLG (1988) Gastrointestinal absorption of intact proteins. Ann Rev Nutr. 8: 329-350.
  8. Boyne PSMH (1967) Oral anti-inflammatory enzyme therapy in injuries in professional footballers. Practitioner 198: 543.
  9. Cichoke AJ, L Marty (1981) The use of proteolytic enzymes with soft tissue athletic injuries. Am Chirop. 32.
  10. Dietrich RE (1965) Oral proteolytic enzymes in the treatment of athletic injuries: a double-blind study. Penn Med J. 68: 35.
  11. Donelly PK (1983) The role of protease in immunoregulation. British J of Surgery. 70: 614-622.
  12. Hall DA (1982) The effect of enzyme therapy on plasma lipid levels in the elderly. Atherosclerosis. 49: 209.
  13. Gebauer F, Micheel B, et al. (1997) Proteolytic enzymes modulate the adhesion molecule CD44 on malignant cells in vitro. Int J Immunotherapy XIII (3/4): 111-119.
  14. Seifert J, Siebrecht P, et al. (1986) Amylase absorption and transport via blood and lymph after oral administration. Digest Biol Sci 41: 1593.
  15. Batkin S, Taussig SJ, Szekerezes J (1988) Antimetastatic effect of bromelain with or without its proteolytic and anticoagulant activity. J Cancer Res Clin Oncol. 114: 507-508.
  16. Metzig C, et al. (1999) Bromelain proteases reduce human platlet aggregration in vitro. In Vivo. 13: 7-12.
  17. Taussig SJ, Batkin S (1988) Bromelain, the enzyme complex of pineapple and its clinical application. J Ethnopharmcol. 22:191-203.
  18. Izaka K, Yamada M, et al. (1972) Gastrointestinal absorption and anti-inflammatory effect of bromelain. Jpn J Pharmacol. 22: 519-534.
  19. Cichoke AJ (1995) The effect of systemic enzyme therapy on cancer cells and the immune system. Townsend Letter for Doctors and Patients. Nov. 1995: 30-32.
  20. Hingorani K (1968) Oral enzyme therapy in severe back pain. Br J Clin Pract. May 1968, 22 (5): 209-10.
  21. Kelly GS, (1996) Bromelain: A literature review and discussion of its therapeutic applications. Alternative Medicine Review (Nov 1, 1996).
  22. Miller JM, Opher AW (1964) The increased proteolytic activity of human blood serum after oral administration of bromelain. Exp Med Surg. 22: 277-280.
  23. Innerfield I, Wernick T (1961) Plasma anti-thrombin alterations following oral papain. Proc Ext Biol Med. 107: 505-506.
  24. Thacker PA, Campbell GL, GrootWassink J (1991) The effect of enzyme supplementation on the nutritive value of rye-based diets for swine. Can J Anim Sci, 71: 489-96.
  25. Laider B, Letourneur M (1993) Enzymatic debridement of leg ulcers using papain. Annal de Dermatol et de Venereologie. 120(3): 248.
  26. Gardner MLG (1988) Gastrointestinal absorption of intact proteins. Ann Rev Nutr. 8:329-350.
  27. Quigley EM, Hurley D (2000) Autism and the gastrointestinal tract. Am J Gastroenterology 95: 2154-2156.
  28. Molis C, Flourie B, et al (1996) Digestion. excretion, and energy value of fructooligosaccharides in healthy humans. Am J Clin Nutr. 64: 324-8.
  29. Alles MS, Hautvast JGAJ, et al. (1996) Fate of fructooligosaccharides in the human intestine. Br J Nutr. 76: 211-21.
  30. Stone-Dorshow T, Levitt MD (1987) Gaseous response to indigestion of a poorly absorbed fructooligosaccharide sweetner. Am J Clin Nutr. 46: 61-5.
  31. Baumhackl C, Fordermair S (1990) Enzyme therapy in multiple sclerosis. Gen Medicine. 19 (4): 169-172.
  32. Goldberg DM (1992) Enzymes as agents for the treatment of disease. Clin Chimi Acta. 206: 45-76.
  33. Gotze H, Rothman SS (1979) Amylase transport across ileal epithelium in vitro. Gastroenterol. Clin Biol. 3: 298.
  34. Gotze H, Rothman SS (1975) Enteropancreatic circulation of digestive enzymes. Nature 257: 607.
  35. Inderst R (1992) Systemic enzyme therapy. J of Pharmacy. 52.
  36. Inderst R (1990) Enzyme therapy in vascular diseases. Gen Medicine. 19 (4): 154-157.
  37. Lotz-Winter H (1990) On the pharmacology of bromelain, an update with special regard to animal studies on dose-dependent effects. Planta Med. 56: 56-249.
  38. Karani S, Kabaria MS, Barber AE (1971) A double-blind clinical trial with a digestive enzyme product. Br J Clin Pract. Aug 1971: 25 (8): 375-7.
  39. Rothman S, Liebow C, Isenman L (2002) Conservation of digestive enzymes. Physiological Reviews. Jan. 2002, 82 (1): 1-18. Review.
  40. Schneeman BO, Gallaher D (1985) Effects of dietary fiber on digestive enzyme activity and bile acids in the small intestine. Proc Soc for Exp Biol and Med. Soc for Exp Biol and Med (New York) Dec. 1985, 180 (3): 409-14.
  41. Rothman SS, Grendell JH (1983) The case of disappearing pancreatic digestive enzymes. Gastroenterology. Dec 1983, 85 (6): 1438-42.
  42. Jager H (1990) Hydrolytic enzymes in the treatment of HIV infections. Allgemeinmedizin 19: 160-164.
  43. Kleine M W, Ertl D (1997) Introduction to oral enzyme therapy and its use in Varicella zoster treatment. Int J Tiss Reac XIX (1/2) – abstracts of 7th intersci world conf on inflammation, antirheumatics, analgesics, immunomodulators, May 19-21, 1997, Geneva, Switzerland.
  44. Donelly PK (1983) The role of protease in immunoregulation. Brit J of Surgery. 70: 614-22.
  45. Guggenbichler JP (1988) Influence of hydrolytic enzymes in thrombi formation and thrombolysis. Medical World (Med Welt.) 39: 227.

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